Author

P. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

S. Chen· 5 shared L. Peng· 4 shared K. Suzuki· 3 shared L. Yang· 3 shared L. Ye· 3 shared P. A. Renauer· 3 shared P. Ren· 3 shared Q. Lin· 3 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBioengineering

S. Chen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

L. Ye, S. Z. Lam, L. Yang, K. Suzuki, Y. Zou, Q. Lin, Y. Zhang, P. Clark, L. Peng, S. Chen

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

bioRxiv · Mar 14, 2023 · PreprintBioengineering

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

P. A. Renauer, J. J. Park, M. Bai, A. Acosta, W.-H. Lee, G. H. Lin, Y. Zhang, X. Dai, G. Wang, Y. Errami, T. Wu, P. Clark, L. Ye, Q. Yang, S. Chen

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

bioRxiv · Mar 14, 2023 · PreprintCancer Biology

The damage-independent evolution of ageing by selective destruction

J. Wordsworth, D. Shanley, H. O'Keefe, P. Clark

This paper proposes an alternative theory to disposable soma theory, suggesting ageing arises from selective destruction of fast-growing cells, leading to metabolic slowdown and increased mortality.

bioRxiv · May 3, 2022Evolutionary Biology

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

P. Ren, L. Peng, Z. Fang, K. Suzuki, P. A. Renauer, Q. Lin, M. Bai, L. Yang, T. Li, P. Clark, D. Klein, S. Chen

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

bioRxiv · Mar 17, 2022 · PreprintBioengineering

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Z. Fang, L. Peng, R. Filler, K. Suzuki, A. McNamara, Q. Lin, P. A. Renauer, L. Yang, B. Menasche, A. Sanchez, P. Ren, Q. Xiong, M. Strine, P. Clark, C. Lin, , S. Chen

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

bioRxiv · Feb 14, 2022Immunology

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

L. Peng, Y. Hu, M. Mankowski, P. Ren, R. Chen, J. Wei, M. Zhao, T. Li, T. Tripler, L. Ye, R. Chow, Z. Fang, C. Wu, M. Dong, M. Cook, , S. Chen

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

bioRxiv · Dec 21, 2021Immunology