D. L. Mack

Far-red and sensitive sensor for monitoring real-time H2O2 dynamics with subcellular resolution and inmulti-parametric imaging applications.

This paper introduces a new fluorescent sensor, oROS-HT, for real-time H2O2 monitoring with subcellular resolution and multi-parametric imaging capabilities.

Structure-guided engineering of a fast genetically encoded sensor for real-time H2O2 monitoring.

This paper develops a fast, sensitive genetically encoded H2O2 sensor (oROS-G) and demonstrates its use in monitoring H2O2 dynamics in various cell types and models.

Dystrophin deficiency impairs cell junction formation during embryonic myogenesis

This study shows that dystrophin deficiency disrupts cell junction formation during embryonic myogenesis in human pluripotent stem cells.

Dystrophin is a mechanical tension modulator

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

Perpendicular Shear Stresses Drive Transmural Helical Remodeling in Engineered Human Ventricular Models

This study shows that perpendicular shear stress drives helical transmural remodeling in engineered human ventricles, revealing how physical forces influence cardiac architecture.

High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing

This paper introduces a magnetic sensing system for real-time monitoring of engineered skeletal muscle function, showing improved contractility over time and enabling drug screening and disease modeling.

AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

The paper uses RNA-sequencing to analyze the transcriptome of canine XLMTM muscle after rAAV8-cMTM1 gene transfer, showing dose-dependent normalization of gene expression and identifying new disease-related transcripts.