D. Lang

Style deflection is determined by the handedness of phyllotaxis and auxin-induced differential cell elongation in a species with mirror-image flowers

This study identifies that floral handedness in Cyanella alba is determined by phyllotactic spiral direction and auxin-induced differential cell elongation, not genetics.

A snapshot of the Physcomitrella N-terminome reveals N-terminal methylation of organellar proteins

The paper analyzes the N-terminome of Physcomitrella to reveal N-terminal methylation of mitochondrial proteins and identifies a methyltransferase involved in plastid, mitochondrial, and cytosolic methylation.

Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure

This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.

Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes

This study identifies GPCRs in SAN pacemaker cardiomyocytes and shows that CCKAR activation slows their firing rate via reduced phase 4 depolarization.

Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.

Establishment of a Patient-Derived, Magnetic Levitation-Based, 3D Spheroid Granuloma Model for Human Tuberculosis.

This paper establishes a 3D spheroid granuloma model for human tuberculosis to study immune responses and drug interventions in a more physiologically relevant environment.

Characterising the epidemic spread of Influenza A/H3N2 within a city through phylogenetics

The paper uses genetic sequence data and patient metadata to analyze local influenza transmission dynamics in Basel, Switzerland, finding that temperature trends correlate with transmission and that elderly and school children drive different transmission networks.

High-resolution influenza mapping of a city reveals socioeconomic determinants of transmission within and between urban quarters

This study maps influenza transmission in a city at high resolution, finding socioeconomic factors like income influence infection patterns and vaccination rates, independent of population density.

Cytoskeletal Tubulin Competes with Actin to Increase Deformability of Metastatic Melanoma Cells

This study shows that metastatic melanoma cells have increased fluidity and cytoskeletal components, which enhance motility while reducing stiffness compared to earlier disease stages.

Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation

The paper introduces 1cell-DGE, a single-cell RNA-sequencing method using microcapillary manipulation to analyze gene expression in intact moss tissues, identifying differentially expressed genes during leaf cell reprogramming.

Genome-skimming provides accurate quantification for pollen mixtures

This study demonstrates that genome-skimming accurately quantifies mixed pollen samples, showing high repeatability and correlation between sequence reads and pollen proportions.