D. Chang

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation

The paper identifies NCBP1 stress signaling that drives alternative S6K1 splicing, inhibiting translation through nuclear reactive electrophile stress.

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

This paper introduces a reagentless electrochemical method using self-assembled monolayers to detect small molecules in biological fluids.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Detection of Cell-Cell Interactions via Photocatalytic Cell Tagging

This paper introduces PhoTag, a method to detect cell-cell interactions by labeling cell surfaces with photocatalytic tags, enabling analysis of gene expression differences between interacting and bystander cells.

The landscape of driver mutations in cutaneous squamous cell carcinoma

This study identifies 30 driver genes in cutaneous squamous cell carcinoma through meta-analysis of sequencing data, highlighting mutations in NOTCH, p53, Hippo, Ras/MAPK/PI3K, cell-cycle checkpoint, and chromatin remodeling pathways.

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

Measuring site-specific glycosylation similarity between influenza A virus variants with statistical certainty

This paper quantifies glycosylation differences between influenza A virus strains to improve vaccine design by understanding how glycosylation affects antigenicity and immune escape.

Complexity and ultrastructure of infectious extracellular vesicles from cells infected by nonenveloped virus

This study identifies the complex composition and structure of infectious extracellular vesicles from non-enveloped virus-infected cells, revealing their role in viral transmission.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

This study shows macrophages in pancreatic cancer release pyrimidines that inhibit gemcitabine therapy by competing with the drug for uptake and metabolism, and reducing macrophage burden improves treatment response.