F. Jacob

De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data

LongSom detects somatic variants in LR scRNA-seq data without normal samples, revealing clonal heterogeneity in ovarian cancer.

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

This study shows SMAC mimetics overcome apoptotic resistance in ovarian cancer by targeting the MSLN-TNF alpha axis, enhancing cell death and synergizing with chemotherapy.

Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer

This study uses long-read single-cell RNA sequencing to detect isoforms and genomic alterations in ovarian cancer, revealing novel isoforms, cell type-specific expression patterns, and gene fusions.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR-T cell testing

This paper describes methods for generating and biobanking glioblastoma organoids from patient tissue and testing CAR-T cell responses through co-culture.

Plant mixed lineage kinase domain-like proteins limit biotrophic pathogen growth

The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.