X. Ling

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Mechanical ventilation affects the microecology of the rat respiratory tract

This study examines how mechanical ventilation impacts the respiratory tract microbiota in rats, finding increased biofilm formation and dispersed microbial clustering.

Rapid, multianalyte detection of opioid metabolites in wastewater

This paper presents an aptamer-based graphene field effect transistor platform for rapid, reliable, and cost-effective detection of three opioid metabolites in wastewater.

Dexmedetomidine attenuates the injury of H9C2 cardiomyocytes under Hypoxia/reoxygenation condition partly through the inhibition of endoplasmic reticulum stress

This study shows that 1 μM Dexmedetomidine reduces H9C2 cardiomyocyte injury under hypoxia/reoxygenation by partially inhibiting endoplasmic reticulum stress.

Dielectrophoresis assisted rapid, selective and single cell detection of antibiotic resistant bacteria with G-FETs

This paper presents a biosensor using G-FETs and dielectrophoresis to rapidly and selectively detect antibiotic-resistant bacteria at the single-cell level.

Comparative molecular life history of spontaneous canine and human gliomas

This study compares molecular profiles of canine and human gliomas to identify conserved mutational processes and similarities in tumor development.

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

The paper introduces a new syngeneic mouse model of spontaneous breast cancer brain metastasis and evaluates histone deacetylase inhibitors as potential therapies.