Author

P. Wesseling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 7

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:DNA methylation· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Weller· 3 shared R. G. Verhaak· 3 shared W. Wick· 3 shared F. P. Barthel· 2 shared I. de Heer· 2 shared K. C. Johnson· 2 shared M. Sanson· 2 shared T. Gorlia· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

M. Weller

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7 papers

Recent·Most cited

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

W. R. Vallentgoed, Y. Hoogstrate, K. A. van Garderen, L. van Hijfte, E. van Dijk, M. C. Kouwenhoven, J. M. Niers, K. Draaisma, I. Martin, W. W. de Leng, C. M. S. Tesileanu, I. de Heer, M. Diepeveen, A. Lavrova, P. P. Eijk, , P. J. French

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

bioRxiv · Mar 5, 2024Cancer Biology

Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in Atypical Teratoid/Rhabdoid Tumors

D. S. Metselaar, M. H. Meel, J. R. Goulding, P. Waranecki, M. C. de Gooijer, M. Breur, J. Koster, S. E. Veldhuijzen van Zanten, M. Bugiani, P. Wesseling, G. J. Kaspers, E. Hulleman

This study shows gemcitabine selectively kills ATRT by degrading SIRT1, activating p53 and SHH signaling, and significantly improves survival in xenograft models.

bioRxiv · Sep 2, 2023Cancer Biology

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

F. S. Varn, K. C. Johnson, T. E. Wade, T. M. Malta, T. S. Sabedot, F. P. Barthel, H. Kim, N. Ahmed, I. Datta, J. S. Barnholtz-Sloan, S. Bakas, F. D'Angelo, H. K. Gan, L. Garofano, J. T. Huse, , The GLASS Consortium

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

bioRxiv · May 3, 2021Cancer Biology

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

M. Tesileanu, W. Vallentgoed, M. Sanson, W. Taal, P. Clement, W. Wick, A. Brandes, J.-F. Baurain, O. Chinot, H. Wheeler, S. Gill, M. Griffin, L. Rogers, R. Ruda, M. Weller, , van den Bent

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

bioRxiv · Dec 10, 2020 · PreprintCancer Biology

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

P. Sievers, M. Sill, D. Schrimpf, D. Stichel, D. E. Reuss, D. Sturm, J. Hench, S. Frank, L. Krskova, A. Vicha, M. Zapotocky, B. Bison, P. N. Harter, M. Snuderl, C. M. Kramm, , F. Sahm

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.

bioRxiv · Aug 28, 2020Cancer Biology

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

N. Verburg, F. P. Barthel, K. J. Anderson, K. C. Johnson, M. Koopman, M. Yaqub, O. Hoekstra, A. Lammertsma, F. Barkhof, P. Pouwels, J. C. Reijneveld, A. Rozemuller, R. Boellaard, M. D. Taylor, S. Das, , R. G. Verhaak

This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.

bioRxiv · Mar 28, 2020 · PreprintCancer Biology

Reconstructing the Molecular Life History of Gliomas

F. Barthel, P. Wesseling, R. Verhaak

This paper proposes a model of gliomagenesis with five phases, linking somatic genomic alterations to tumor development and suggesting therapeutic strategies.

bioRxiv · Sep 29, 2017Cancer Biology