F. Sun

This study investigates the molecular mechanism of PA transfer by Ups1/Mdm35 using crystal structures, molecular dynamics simulations, and biophysical assays, revealing conformational changes and regulatory factors.

The paper uses cryo-EM to study SOPA1's structure and conformational changes upon GTP binding, revealing its unique mechanism in mitochondrial membrane fusion.

This study identifies two regions on MiD51 that bind Drp1 and shows that MiD51 dimerization via a disulfide bond is required for Drp1 recruitment, revealing a multi-faceted regulatory mechanism for mitochondrial fission.

The paper develops a workflow for preparing micro/nano-crystals for MicroED, enabling the study of small macromolecular crystals previously unsuitable for this technique.