G. Church

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

The paper compares EV isolation methods using Simoa assays to quantify EV markers and assess efficiency and purity in plasma and CSF.

This paper demonstrates that intranasal and injectable CMV-based gene therapy can extend lifespan and improve health in mice by overexpressing TERT and FST.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

The paper uses deep neural networks to predict toehold switch function in RNA synthetic biology, outperforming existing models and providing visual insights into their behavior.

The paper reviews the claim of inter-homologue repair in human embryos using CRISPR-Cas9 and discusses biological constraints and alternative explanations for the observed data.