Author

H. Bell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:metabolomics· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. A. Lyssiotis· 3 shared Y. M. Shah· 3 shared N. K. Das· 2 shared R. Banerjee· 2 shared R. Kumar· 2 shared R. Singhal· 2 shared S. A. Kerk· 2 shared A. Andren· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

C. A. Lyssiotis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

R. Kumar, V. Vitvitsky, P. Seth, H. L. Hiraki, H. Bell, A. Andren, R. Singhal, B. Baker, C. A. Lyssiotis, Y. M. Shah, R. Banerjee

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

Nature Chemical Biology · Mar 20, 2024Peer-reviewedBiochemistry

Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D beta-lactamases.

Q. Zhou, H. Bell, P. Catalan, P. Baumann, R. Evans, J. Yang, Z. Zhang, D. Zappala, Y. Zhang, G. M. Blackburn, Y. He, Y. Jin

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

bioRxiv · Dec 20, 2022 · PreprintBiochemistry

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth

H. Bell, J. Goyert, S. A. Kerk, N. K. Das, C. A. Lyssiotis, Y. M. Shah

This study identifies reuterin as a microbial metabolite that suppresses colorectal cancer growth by altering redox balance and inducing cell death.

bioRxiv · Dec 2, 2020 · PreprintCancer Biology