Author

T. L. Frankel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Pasca di Magliano· 4 shared A. Rao· 2 shared C. A. Lyssiotis· 2 shared C. Espinoza· 2 shared F. Bednar· 2 shared F. Lima· 2 shared K. L. Donahue· 2 shared N. G. Steele· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

M. Pasca di Magliano

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4 papers

Recent·Most cited

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in Mice

I. Barravecchia, J. M. Lee, J. Manassa, B. Magnuson, S. Cavanaugh, N. G. Steele, C. Espinoza, C. J. Galban, N. Ramnath, T. L. Frankel, M. Pasca di Magliano, S. Galban

This study develops a mouse model to investigate how IPF-related fibrosis influences lung cancer development and identifies immune-suppressive mechanisms and therapeutic targets.

bioRxiv · Jun 20, 2023Cancer Biology

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

E. S. Carpenter, A. M. Elhossiny, P. Kadiyala, J. Li, J. McGue, B. Griffith, Y. Zhang, J. Edwards, S. Nelson, F. Lima, K. L. Donahue, W. Du, A. C. Bischoff, D. Alomari, H. Watkoske, , M. Pasca Di Magliano

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology