The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation
T. I. Tithi, J. Mo, N. Borcherding, S. Jo, E. Cho, K. E. Cash, M. Honda, L. Wang, K. K. Ahmed, K. Shirlekar, L. Chen, R. Weigel, H. Kates, K. Gibson-Corley, M. Spies, , W. Zhang
This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.
bioRxiv · Jul 20, 2023 · PreprintCancer Biology