T. Yi

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Presence of NCOR1+/CD4+ T cells in tertiary lymphoid organ predicts favorable prognosis in pancreatic ductal adenocarcinoma

The paper shows that NCOR1+/CD4+ T cells in tertiary lymphoid organs predict better outcomes in pancreatic ductal adenocarcinoma patients.

Malignant tumors engender and employ cancer-specific organelles for self-protection and metastasis

This study identifies cytocapsular oncocells and their networks as key structures driving cancer progression and metastasis through membrane-enclosed systems.

Genome duplications, genomic conflict, and rapid phenotypic evolution characterize the Cretaceous radiation of Fagales

This study examines the relationship between phenotypic and genomic evolution in Fagales, finding an 'early burst' model of diversification linked to gene duplication and genomic conflict during the Cretaceous.

Phylogenomic Analyses Reveal Widespread Gene Flow During the Early Radiation of Oaks and Relatives (Fagaceae: Quercoideae)

This study uses phylogenomic data to show widespread gene flow and reticulation during the early radiation of oaks and related genera.

Comparative Phylogenomics and Phylotranscriptomics Provide Insights into the Genetic Complexity of Nitrogen Fixing Root Nodule Symbiosis

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

Two shifts in evolutionary lability underlie independent gains and losses of root-nodule symbiosis in a single clade of plants

The paper reconstructs the evolutionary history of root-nodule symbiosis in the nitrogen-fixing clade, identifying a two-step process involving shifts in evolutionary lability that explain multiple independent gains and losses of the trait.

Cytocapsular cancer evolution analyses of 311 kinds of cancers

This study maps cytocapsular cancer evolution across 311 cancer types, revealing shared and distinct evolutionary processes in solid and liquid cancers.

Cytocapsulae and cytocapsular tubes are golden targets for precise, effective and efficient cancer diagnosis and therapy in 307 kinds of liquid and solid cancers

The paper investigates the structural compartments of cancer cells and tumors in 307 cancers using clinical specimens and IHC images, identifying cytocapsular tubes and their role in cancer evolution.

Cytocapsular tube network-tumor system is an integrated physical target for the highly effective and efficient pharmacotherapy of solid cancers

This study shows that conventional tumor models do not form CCT networks, explaining poor drug efficacy, and suggests using CCT xenografts for better drug development.

Cytocapsular tubes and networks function as physical superdefence freeway systems conducting conventional cancer drug pan-resistant tumor metastasis

This study identifies cytocapsular tubes (CCTs) as physical barriers enhancing cancer drug resistance and metastasis, and develops a CCT xenograft platform for drug development.

Cancer Metastases of 202 Kinds of Cancers via Cytocapsular Tubes

The paper identifies cytocapsular tubes as a physical pathway for cancer metastasis, showing their presence in all cancer and metastatic tissues but not in normal or benign tissues.

Selective Optogenetic Stimulation of Glutamatergic, but not GABAergic, Vestibular Nuclei Neurons Induces Immediate and Reversible Postural Imbalance in Mice

This paper uses optogenetics to show that glutamatergic vestibular nuclei neurons, but not GABAergic ones, cause immediate postural imbalance in mice.