Author

J. Druce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:variant calling· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. Caly· 2 shared M. Catton· 2 shared T. Tran· 2 shared A. Greenhalgh· 1 shared A. Luttick· 1 shared B. Jones· 1 shared B. P. Howden· 1 shared C. Hartley· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

L. Caly

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

T. Prince, X. Dong, R. Penrice-Randal, N. Randle, C. Hartley, H. Goldswain, B. Jones, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, ISARIC4C Investigators, G. Hughes, E. Anderson, E. I. Patterson, , J. A. Hiscox

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology

Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

J. Y. Lee, N. Best, J. L. McAuley, J. Porter, T. Seemann, M. B. Schultz, M. Sait, N. Orlando, K. Mercoulia, S. A. Ballard, J. Druce, T. Tran, M. Catton, M. J. Pryor, H. L. Cui, , T. P. Stinear

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

Journal of Medical Microbiology · Sep 1, 2020Peer-reviewedMicrobiology

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

N. Ogando, T. Dalebout, J. C. Zevenhoven-Dobbe, R. W. A. L. Limpens, Y. van der Meer, L. Caly, J. Druce, J. de Vries, M. Kikkert, M. Barcena, I. Sidorov, E. J. Snijder

This study compares SARS-CoV-2 and SARS-CoV replication in Vero E6 cells, finding higher viral RNA levels in SARS-CoV-2 but lower infectious progeny, and adaptive mutations in its spike protein.

bioRxiv · Apr 20, 2020Microbiology

Direct RNA sequencing and early evolution of SARS-CoV-2

G. Taiaroa, D. Rawlinson, L. Featherstone, M. Pitt, L. Caly, J. Druce, D. Purcell, L. Harty, T. Tran, J. Roberts, N. Scott, M. Catton, D. Williamson, L. Coin, S. Duchene

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

bioRxiv · Mar 5, 2020 · PreprintMicrobiology