J. Holly

Viral Syncytia Evolve to Resist Interferon

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.

C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire

This study shows that C1q enhances anti-hemagglutinin stem antibody neutralization by blocking viral attachment and expanding the viral escape repertoire.

Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

The paper measures protein synthesis rates in lymphocytes and finds that their in vivo elongation rates increase with activation, despite a high protein-to-ribosome ratio suggesting insufficient capacity for rapid division.

Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity

This study shows SARS-CoV-2 nucleocapsid protein binds to chemokines and modulates immune responses, suggesting it as a target for cross-reactive vaccines.

Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologs

This paper develops a cell-based assay to measure SARS-CoV-2 Spike protein binding and infectivity across ACE2 orthologs by normalizing ACE2 expression levels using a reporter protein.

Genome-wide Screens Identify Lineage- and Tumor Specific-Genes Modulating MHC-I and MHC-II Immunosurveillance in Human Lymphomas

The paper identifies genes modulating MHC-I and MHC-II expression in lymphomas, revealing potential targets for immunosurveillance manipulation.