Author

J. LaClair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. Sawyers· 2 shared J. Love· 2 shared A. C. A. Rivera· 1 shared C.-C. Chen· 1 shared D. Choi· 1 shared D. Pe'er· 1 shared E. Lee· 1 shared E. Linton· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

C. Sawyers

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2 papers

Recent·Most cited

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

E. Lee, Z. Zhang, C.-C. Chen, D. Choi, A. C. A. Rivera, E. Linton, Y.-j. Ho, J. Love, J. LaClair, J. Wongvipat, C. Sawyers

This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.

bioRxiv · Mar 18, 2024 · PreprintCancer Biology

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

W. Karthaus, J. Chan, M. Setty, J. Love, S. Zaidi, Z.-N. Choo, S. Persad, J. LaClair, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, D. Pe'er, C. Sawyers

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology