Author

K. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Zheng· 2 shared C. Zhao· 2 shared D. Pe'er· 2 shared I. Masilionis· 2 shared L. Mazutis· 2 shared L. Ye· 2 shared O. Chaudhary· 2 shared R. Chaligne· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

A. Zheng

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

A. Zheng, J. Jiang, C. Zhao, X. Zhang, J. Hao, L. Ye, K. Lawrence, Y. Lu, C. Du, X. Si, H. Xu, Q. Yang, Q. Xia, G. Yu, F. Yuan

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

bioRxiv · Jan 30, 2022 · PreprintMicrobiology

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

W. Karthaus, J. Chan, M. Setty, J. Love, S. Zaidi, Z.-N. Choo, S. Persad, J. LaClair, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, D. Pe'er, C. Sawyers

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

A. Zheng, Z. Zhang, G. Zhang, X. Zhan, X. Zhang, C. Zhao, C. Cheng, H. Li, T. Yu, K. Lawrence, J. Sun, Z. Yang, L. Ye, H. Chu, Y. Wang, , Y. K. Choi

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

bioRxiv · Oct 20, 2021 · PreprintEvolutionary Biology

Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach

X. Cao, J. Maruyama, H. Zhou, L. Kerwin, R. Sattler, J. T. Manning, S. Johnson, S. Richards, Y. Li, W. Shen, B. Blair, N. Du, K. Morais, K. Lawrence, L. Lu, , R. D. Allen

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

bioRxiv · Sep 27, 2020 · PreprintMicrobiology