Author

J. Pollara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:rat· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2

Frequent Co-Authors

S. R. Permar· 6 shared G. Ferrari· 3 shared K. De Paris· 3 shared K. K. A. Van Rompay· 3 shared M. Dennis· 3 shared R. Goswami· 3 shared A. D. Curtis· 2 shared A. Kumar· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersImmunology

S. R. Permar

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8 papers

Recent·Most cited

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

C. E. Otero, R. Barfield, E. Scheef, C. S. Nelson, N. Rodgers, H.-Y. Wang, M. Moström, T. D. Manuel, J. Sass, K. Schmidt, H. Taher, C. Papen, L. Sprehe, S. Kendall, A. Davalos, , S. R. Permar

This study investigates maternal cytomegalovirus (CMV) antibody responses and viral load in rhesus macaques to determine their association with vertical transmission risk, finding no link between plasma viremia or humoral responses and congenital CMV in immunocompetent dams.

PLOS Pathogens · Oct 23, 2023Peer-reviewedImmunology

Vaccine-induced, high magnitude HIV Env-specific antibodies with Fc-mediated effector functions are insufficient to protect infant rhesus macaques against oral SHIV infection

A. D. Curtis, P. T. Saha, M. Dennis, S. J. Berendam, S. M. Alam, G. Ferrari, P. A. Kozlowski, G. G. Fouda, M. G. Hudgens, K. K. A. Van Rompay, J. Pollara, S. R. Permar, K. De Paris

This study tests a vaccine regimen in infant rhesus macaques, finding that Env-specific antibodies with Fc effector functions do not prevent oral SHIV infection.

bioRxiv · Oct 11, 2021Immunology

HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization

C. Nelson, J. Jenks, N. Pardi, M. Goodwin, H. Roark, W. Edwards, J. McClellan, J. Pollara, D. Weissman, S. Permar

This study compares gB mRNA-LNP vaccine with gB protein vaccines, finding that mRNA-LNP elicits more durable and broadly reactive antibodies against HCMV glycoprotein B.

bioRxiv · Oct 8, 2019Immunology

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

R. Goswami, A. N. Nelson, J. J. Tu, M. Dennis, L. Feng, A. Kumar, J. Mangold, R. J. Mangan, C. Mattingly, A. D. Curtis, V. Obregon-Perko, M. Mavigner, J. Pollara, G. M. Shaw, K. J. Bar, , S. R. Permar

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

bioRxiv · Jun 11, 2019Immunology

Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity

D. Easterhoff, J. Pollara, K. Luo, W. D. Tolbert, B. Young, D. Mielke, S. Jha, R. J. O'Connell, S. Vasan, J. Kim, N. Michael, J.-L. Excler, M. L. Robb, S. Rerks-Ngarm, J. Kaewkungwal, , G. Ferrari

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

bioRxiv · May 9, 2019 · PreprintImmunology

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

A. N. Nelson, R. Goswami, M. Dennis, J. Tu, R. Mangan, P. T. Saha, D. W. Cain, X. Shen, G. M. Shaw, K. J. Bar, M. G. Hudgens, J. Pollara, K. De Paris, K. K. A. Van Rompay, S. R. Permar

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

bioRxiv · Feb 2, 2019Immunology

HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions

C. S. Nelson, T. Huffman, E. Cisneros de la Rosa, G. Xi, N. Vandergrift, R. F. Pass, J. Pollara, S. R. Permar

This paper shows that the HCMV gB/MF59 vaccine's 50% efficacy is due to non-neutralizing antibodies that mediate virion phagocytosis, not neutralization.

bioRxiv · Jan 11, 2018Immunology

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.

J. E. Himes, R. Goswami, R. J. Mangan, A. Kumar, T. L. Jeffries, J. A. Eudailey, H. Heimsath, Q. N. Nguyen, J. Pollara, C. LaBranche, M. Chen, N. A. Vandergrift, J. W. Peacock, F. Schiro, C. Midkiff, , S. R. Permar

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.

bioRxiv · Jun 3, 2017Immunology