Author

J. Tu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3 Cell Biology· 2 Microbiology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Organism:human· 10 Assay:proteomics· 7 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell-cell communication· 3 Organism:mouse· 3

Frequent Co-Authors

S. R. Permar· 4 shared A. Kumar· 3 shared C. Yang· 3 shared D. Martinez· 2 shared D. Wrapp· 2 shared F. Gao· 2 shared J. A. Jenks· 2 shared J. S. McLellan· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersImmunology

S. R. Permar

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Programmable Editing of Primary MicroRNA Switches Stem Cell Differentiation and Improves Tissue Regeneration

V. A. Truong, Y.-H. Chang, Y. Tu, N. T. K. Nguyen, N. N. Pham, C.-W. Chang, Y.-H. Chang, D. T. K. Ngo, D. H. Pham, J. Tu, Q. T. Dang, V. A. Truong, Y.-C. Hu

The paper introduces REPRESS, a tool for editing pri-miRNA to suppress miRNA, and demonstrates its application in stem cell differentiation and tissue regeneration.

bioRxiv · Jul 19, 2024Bioengineering

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

F. Yue, A. T. Ku, P. Stevens, M. Michalski, W. Jiang, J. Tu, Z. Shi, Y. Dou, Y. Wang, X.-H. Feng, G. Hostetter, X. Wu, S. Huang, N. Shroyer, B. Zhang, , Y. Li

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

bioRxiv · Jan 10, 2024Cancer Biology

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

W. Li, J. Tu, J. Zheng, A. Das, Q. Yan, X. Jiang, W. Ding, X. Bai, K. Lai, S. Yang, C. Yang, J. Zou, A. D. Diwan, Z. Zheng

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

bioRxiv · Jul 26, 2023 · PreprintCell Biology

Exogenous Recombinant N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B; ARSB) Inhibits Progression of B16F10 Cutaneous Melanomas and Modulates Cell Signaling

S. Bhattacharyya, I. O-Sullivan, J. Tu, Z. Chen, J. K. Tobacman

This study shows that exogenous ARSB treatment reduces B16F10 melanoma tumor size and improves survival by altering chondroitin sulfate levels and modulating cell signaling pathways.

bioRxiv · May 30, 2023Cancer Biology

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

J. Tu, A. Kumar, E. Giorgi, J. A. Eudailey, C. LaBranche, D. Martinez, G. G. Fouda, Y. Moreau, A. Thomas, D. Montefiori, F. Gao, M. Sagar, S. R. Permar

This study examines maternal broadly neutralizing antibody (bnAb) specificities in HIV-transmitting and non-transmitting mothers to determine if certain bnAb specificities drive infant transmitted/founder virus selection.

bioRxiv · Feb 3, 2022Immunology

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

J. A. Jenks, S. Amin, A. Kumar, M. R. Sponholtz, D. Wrapp, S. Venkatayogi, J. Tu, J. S. McLellan, K. Wiehe, S. R. Permar

bioRxiv · Jan 19, 2022Microbiology

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

J. Tu, W. Li, S. Yang, P. Yang, Q. Yan, S. Wang, K. Lai, X. Bai, C. Wu, W. Ding, J. Cooper-White, A. Diwan, C. Yang, H. Yang, J. Zou

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

bioRxiv · May 25, 2021Cell Biology

BnaA03.WRKY28, interacting with BnaA09.VQ12, acts as a brake factor of activated BnWRKY33-mediated resistance outburst against Sclerotinia sclerotiorum in Brassica napus

J. Tu, K. Zhang, F. Liu, Z. Wang, C. Zhuo, K. Hu, X. Li, J. Wen, B. Yi, J. Shen, C. Ma, T. Fu

Under constant infection by Sclerotinia sclerotiorum, BnaA03.WRKY28 interacts with BnaA09.VQ12 and takes precedence over phosphorylated BnWRKY33 to bind to the BnWRKY33 promoter, thereby weakening resistance but promoting branching.

bioRxiv · Jan 28, 2021 · PreprintPlant Biology

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection pressure in fetuses

M. H. Marichannegowda, M. Mengual, A. Kumar, E. E. Giorgi, J. Tu, D. Martinez, X. Li, L. Feng, S. Permar, F. Gao

This study analyzes HIV-1 env gene evolution in 12 perinatal transmission pairs, finding that most infections occur within two months of birth and fetal viruses show unique selection pressures.

bioRxiv · Aug 28, 2020Microbiology

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

M. L. Goodwin, H. S. Webster, H.-Y. Wang, J. A. Jenks, C. S. Nelson, J. Tu, J. Mangold, S. Valencia, J. S. McLellan, D. Wrapp, T.-M. Fu, N. Zhang, D. Freed, D. Wang, Z. An, S. R. Permar

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

bioRxiv · Jan 14, 2020Immunology

The most common RNF43 mutant G659Vfs41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis

J. Tu, S. Park, W. A. Yu, S. Zhang, L. Wu, K. S. Carmon, Q. J. Liu

The paper shows that the RNF43-G659Vfs41 mutation is functional and not a driver mutation in tumorigenesis, but may be a passenger mutation in MLH1-downregulated tumors.

bioRxiv · Jul 22, 2019Cancer Biology

Membrane association of VAMP2 SNARE motif in cells and its regulation by different lipid phases of synaptic vesicle membrane

C. Wang, J. Tu, S. Zhang, B. Cai, Z. Liu, S. Hou, Z. Liu, J. Diao, Z.-J. Zhu, C. Liu, D. Li

This study investigates how lipid phases in synaptic vesicle membranes regulate the structure and function of the VAMP2 SNARE motif using in-cell NMR and lipidomic profiling.

bioRxiv · Mar 24, 2019 · PreprintBiophysics

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

A. N. Nelson, R. Goswami, M. Dennis, J. Tu, R. Mangan, P. T. Saha, D. W. Cain, X. Shen, G. M. Shaw, K. J. Bar, M. G. Hudgens, J. Pollara, K. De Paris, K. K. A. Van Rompay, S. R. Permar

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

bioRxiv · Feb 2, 2019Immunology

Structural and biochemical characterization on the cognate and heterologous interactions of the MazEF-mt9 TA system

R. Chen, J. Tu, Y. Tan, X. Cai, C. Yang, X. Deng, B. Su, S. Ma, X. Liu, P. Ma, C. Du, W. Xie

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.

bioRxiv · Oct 2, 2018Biochemistry