Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
S. Chiou, A. Al-Ani, Y. Pan, K. Patel, I. Kong, L. Whitehead, A. Light, S. Young, M. Barrios, C. Sargeant, P. Rajasekhar, L. Zhu, A. Hempel, A. Lin, J. Rickard, , A. L. Samson
The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.
bioRxiv · Oct 31, 2023Cell Biology
X. S. Wang, T. R. Cotton, S. J. Trevelyan, L. W. Richardson, W. T. Lee, J. Silke, B. C. Lechtenberg
This study defines the core catalytic mechanism of RBR E3 ligases through structural and biochemical analysis of HOIL-1 and RNF216, revealing conserved features and an allosteric mechanism.
bioRxiv · Oct 11, 2022Biochemistry
S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand
The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.
bioRxiv · Sep 8, 2022 · PreprintImmunology
L. Liu, J. J. Sandow, D. M. Leslie Pedrioli, N. Silke, Z. Hu, E. Morrish, D. Chau, T. Kratina, A. J. M. Kueh, M. O. Hottiger, A. I. Webb, N. Lalaoui, J. Silke
This study identifies tankyrase-mediated ADP-ribosylation as a regulator of TNF-induced cell death by promoting complex 2 assembly and interacting with RNF146.
bioRxiv · Feb 9, 2021Cell Biology
V. J. Heim, L. F. Dagley, C. Stafford, F. M. Hansen, E. Clayer, A. Bankovacki, A. I. Webb, I. S. Lucet, J. Silke, U. Nachbur
The paper identifies a regulatory interface on RIPK2 essential for XIAP binding and NOD signaling by analyzing post-translational modifications in RIPK2 knock-in mice.
bioRxiv · Mar 12, 2020Cell Biology