Author

J. Varghese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

R. Gourlay· 3 shared D. G. Campbell· 2 shared G. P. Sapkota· 2 shared T. Macartney· 2 shared A. Derrico· 1 shared A. J. Whitworth· 1 shared A. Knebel· 1 shared A. McKie· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

R. Gourlay

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Microvascular immunity is organ-specific and concealed in peripheral blood

R. Rixen, P. Schuetz, C. Walter, B. Huechtmann, V. Van Marck, B. Heitplatz, J. Varghese, H. Pavenstaedt, K. Buscher

The paper analyzes microvascular immune cells in mouse organs and compares them to peripheral blood, finding organ-specific immune responses that are not detectable in blood or tissue samples.

bioRxiv · Apr 2, 2024 · PreprintImmunology

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

A. Waddell, H. Ojha, S. Agarwal, C. Clarke, A. Terriente-Felix, H. Zhou, P. Kakade, A. Knebel, A. Shaw, R. Gourlay, J. Varghese, R. Soares, R. Toth, T. Macartney, P. Eyers, , M. Muqit

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin

J. V. James, J. Varghese, N. M. John, J. C. Deschemin, S. Vaulont, A. McKie, M. Jacob

This study shows that hepcidin deficiency reduces insulin resistance and adipose tissue inflammation in mice fed a high-fat diet.

bioRxiv · Sep 12, 2021Immunology

Elevated SARS-CoV-2 Antibodies Distinguish Severe Disease in Early COVID-19 Infection

N. S. Haddad, D. C. Nguyen, M. E. Kuruvilla, A. Morrison-Porter, F. Anam, K. S. Cashman, R. P. Ramonell, S. Kyu, A. S. Saini, M. Cabrera-Mora, A. Derrico, D. Alter, J. D. Roback, M. Horwath, J. B. O'Keefe, , F. E.-H. Lee

This paper develops a multiplex immunoassay to measure SARS-CoV-2 antibody responses and finds that severe COVID-19 is associated with higher early antibody levels against S1 and N proteins.

bioRxiv · Dec 4, 2020 · PreprintImmunology

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

L. J. Fulcher, Z. He, L. Mei, T. Macartney, N. Wood, A. R. Prescott, A. Whigham, J. Varghese, R. Gourlay, G. Ball, R. G. Clarke, D. G. Campbell, C. A. Maxwell, G. P. Sapkota

This study identifies FAM83D as a scaffold that recruits CK1α to the mitotic spindle, ensuring proper spindle positioning and timely cell division.

bioRxiv · Nov 27, 2018Cell Biology

FAM83G/PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

G. P. Sapkota, T. D. Cummins, K. Z. L. Wu, P. Bozatzi, K. S. Dingwell, T. J. Macartney, N. T. Wood, J. Varghese, R. Gourlay, D. G. Campbell, A. Prescott, E. Griffis, J. C. Smith

The paper shows PAWS1/FAM83G regulates cell migration by controlling F-actin organization and focal adhesion dynamics through its interaction with CD2AP.

bioRxiv · Feb 8, 2017Cell Biology