J. Chun

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Baculoviral COVID-19 Delta DNA vaccine cross-protects against SARS-CoV2 variants in K18-ACE2 transgenic mice

This paper develops a baculoviral DNA vaccine targeting the SARS-CoV2 Delta variant, showing 100% survival against Delta and Omicron in mice, compared to 50% survival with the original vaccine.

Metagenomic association analysis of gut symbiont Lactobacillus reuteri without host-specific genome isolation

This paper introduces a metagenomic approach to study host-specificity of Lactobacillus reuteri without genome isolation, showing consistent results with prior findings and novel associations in dogs.

Deletion of Sphingosine 1-Phosphate Receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis

This study shows that deleting S1P1 in cardiomyocytes during development causes ventricular hypertrabeculation, fibrosis, and conduction abnormalities, despite preserved systolic function.

Conditional Lpar1 gene targeting identifies cell types mediating neuropathic pain

The paper generates a conditional Lpar1 knockout mouse to identify cell types mediating neuropathic pain, finding that Schwann cells and neurons, but not microglia, are involved.

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosis.

This study identifies a proteolytic cleavage mechanism in INF2 that affects its function in podocytes, leading to impaired localization and contributing to FSGS.