The paper investigates how linker length affects phase separation in the Rubisco-EPYC1 system of green algae, finding that shorter linkers significantly reduce critical concentrations.

bioRxiv · Jun 11, 2023 · PreprintBiophysics

Dietary methionine restriction impairs anti-tumor immunity through gut microbiota

M. Ji, X. Xu, Q. Xu, X. Xu, M. A. Azcarate-Peril, X. Wu, J. Liu, J. W. Locasale, J.-L. Li, I. Shats, X. Li

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

bioRxiv · Aug 27, 2021 · PreprintCancer Biology

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc- SMPDL3B

X. Li, W. Fan, S. Tang, X. Fan, Y. Fang, X. Xu, L. Li, J. Xu, J.-L. Li, Z. Wang

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

eLife · May 27, 2021Peer-reviewedCell Biology

The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis

I. Mahmud, G. Tian, J. Wang, J. Lewis, A. Waddell, M. L. Lydon, L. Y. Zhao, J.-L. Li, H. T. Purayil, Z. Huo, Y. Daaka, T. J. Garrett, D. Liao

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

bioRxiv · Dec 31, 2020 · PreprintCancer Biology