M. Ji

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Novel Murine models of Mania and Depression

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

Distinct denitrifying phenotypes of predominant bacteria mould nitrous oxide metabolism in upland agricultural soils

The paper investigates N2O emissions in two agricultural soils by analyzing denitrifying bacterial communities and their metabolic phenotypes, finding that differences in bacterial composition and gene function drive variations in N2O accumulation.

Introduction of a condensed, reverse tricarboxylic acid cycle for additional CO2 fixation in plants

This paper introduces a synthetic carbon fixation cycle in plants that fixes CO2 without RuBisCO, showing increased photosynthetic capacity in transgenic Camelina sativa.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22)

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

Dietary methionine restriction impairs anti-tumor immunity through gut microbiota

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

The immunodominant and neutralization linear epitopes for SARS-CoV-2

This study identifies immunodominant and neutralizing epitopes on SARS-CoV-2 proteins through computational simulation and experimental validation in mice.

Augmenting Vascular Disease Diagnosis by Vasculature-awareUnsupervised Learning

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

Network Inference from Multi-omic Data Uncovers Dynamic Transcriptional Regulation Modules in Pathogenic Fungus Fusarium graminearum

This paper infers dynamic transcriptional regulatory networks in Fusarium graminearum using multi-omic data and a Bayesian network algorithm, revealing condition-specific modules and their associations with phenotypes.

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

This study identifies genes that tumor cells use to resist T cell killing and shows that inhibiting BIRC2, ITGAV, or DNPEP enhances T cell-mediated tumor destruction.

HIV-1 Nef interacts with LMP7 to attenuate immunoproteasome formation and MHC-I antigen presentation

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

Effective soil extraction method for cultivating previously uncultured soil bacteria

The paper introduces a new soil extract medium (ISEM) that isolates previously uncultured bacteria, with 49% of isolates being previously uncultured and 55% representing new taxonomic candidates.