R. Wei

From Bulk to Binding: Decoding the Entry of PET into Hydrolase Binding Pockets

The paper uses molecular dynamics simulations to uncover the binding pathway of PET hydrolases into PET material and identifies key residues affecting PET entry.

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Selective cleavage of ncRNA and antiviral activity by human RNase2/EDN in a macrophage infection model

This study shows RNase2/EDN cleaves specific ncRNAs and enhances antiviral activity in macrophages against RSV by targeting tRNA-derived fragments and miRNAs.

Comparison of proton transfer paths to the QA and QB sites of the Rb. sphaeroides photosynthetic reaction centers

The paper compares proton transfer paths to the QA and QB sites in Rb. sphaeroides reaction centers using molecular dynamics, finding QA is isolated while QB has a complex network involving multiple surface residues.

Characterizing protein protonation microstates using Monte Carlo sampling

The paper characterizes protonation microstates of proteins using Monte Carlo sampling, showing energy differences and correlations between residues in different pH conditions and reaction intermediates.

Revealing the function of HMGB1 N-terminal acetylation by a protein semi-synthesis approach

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

AFEchidna is a R package for genetic evaluation of plant and animal breeding datasets

AFEchidna is an R package that simplifies genetic analysis in breeding datasets by implementing mixed linear models for variance components and BLUP predictions.

Fructose Metabolism Contributes to the Warburg effect

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

Bio-upcycling of polyethylene terephthalate

This paper presents a novel method to convert polyethylene terephthalate into two bioplastics using enzymatic hydrolysis and microbial fermentation.

Phylogenomics of Selaginellaceae with special reference to the enigmatic sanguinolenta group

This study performs phylogenomic analyses of Selaginellaceae, resolving the position of the sanguinolenta group and identifying factors influencing substitution rates in plastomes.

Polyploidy and elevation contribute to opposing latitudinal gradients in diversification and species richness in lady ferns (Athyriaceae)

This study examines how polyploidy and elevation influence diversification rates and species richness in lady ferns, finding that polyploids have higher net accumulation but lower diversification rates compared to diploids.

PorSignDB: a database of in vivo perturbation signatures for dissecting clinical outcome of PCV2 infection

This paper introduces PorSignDB, a gene signature database that reveals distinct immunotranscriptomic states of PCV2 infection and identifies STAT3 as a druggable host factor.

PGC-1α coordinates with Bcl-2 to control cell cycle in U251 cells through reducing ROS

The paper shows PGC-1α and Bcl-2 work together to reduce ROS and delay cell cycle progression in U251 cells after serum depletion.