The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration
P. Chen, Y. Li, F. Xu, Z. Zhang, T. Zuo, J. Guo, K. Li, S. Liu, S. Li, J. Yin, L. Chang, P. Kukic, M. Liddell, L. Tulum, P. Carmichael, , P. Xu
This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.
Chemosphere · Dec 1, 2023Peer-reviewedPharmacology & Toxicology