Author

M. D. Lessard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Bewersdorf· 3 shared J. E. Rothman· 2 shared L. K. Schroeder· 2 shared P. Kidd· 2 shared Y. Song· 2 shared A. E. Barentine· 1 shared A. Patel· 1 shared A. Qin· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

J. Bewersdorf

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Author profile →

3 papers

Recent·Most cited

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies

G. Biancon, P. Joshi, J. T. Zimmer, T. Hunck, Y. Gao, M. D. Lessard, E. Courchaine, A. E. Barentine, M. Machyna, V. Botti, A. Qin, R. Gbyli, A. Patel, Y. Song, L. Kiefer, , S. Halene

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

bioRxiv · Apr 22, 2021Cancer Biology

3D Adaptive Optical Nanoscopy for Thick Specimen Imaging at sub-50 nm Resolution

X. Hao, E. S. Allgeyer, J. Antonello, K. Watters, J. A. Gerdes, L. K. Schroeder, F. Bottanelli, J. Zhao, P. Kidd, M. D. Lessard, J. E. Rothman, L. Cooley, T. Biederer, M. J. Booth, J. Bewersdorf

This paper develops a 3D adaptive optical nanoscopy technique that achieves sub-50 nm resolution in thick specimens by addressing optical aberrations.

bioRxiv · Nov 25, 2020Biophysics

Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging

Y. Zhang, L. K. Schroeder, M. D. Lessard, P. Kidd, J. Chung, Y. Song, L. Benedetti, Y. Li, J. Ries, P. De Camilli, J. E. Rothman, D. Baddeley, J. Bewersdorf

This paper introduces a super-resolution microscope that images whole mammalian cells at ~20 nm 3D resolution, revealing complex cellular structures previously only visible via electron microscopy.

bioRxiv · Apr 18, 2019Biophysics