Author

E. E. Gardner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

H. Varmus· 3 shared B. D. Stein· 2 shared C. Zhang· 2 shared L. C. Cantley· 2 shared A. K. Challa· 1 shared A. Katti· 1 shared A. M. Laughney· 1 shared A. N. Turner· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

H. Varmus

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Author profile →

5 papers

Recent·Most cited

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

H. Chen, E. E. Gardner, Y. Shah, K. Zhang, A. Thakur, C. Zhang, O. Elemento, H. Varmus

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

bioRxiv · Oct 6, 2023 · PreprintCancer Biology

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

E. E. Gardner, E. M. Earlie, K. Li, J. Thomas, M. J. Hubisz, B. D. Stein, C. Zhang, L. C. Cantley, A. M. Laughney, H. Varmus

The paper models histological transformation of lung cancer and identifies neuroendocrine-specific tolerance to Myc as an oncogenic driver.

bioRxiv · Jun 21, 2023Cancer Biology

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

A. Katti, M. Foronda, J. Zimmermann, M. P. Zafra, S. Goswami, E. E. Gardner, B. J. Diaz, J. M. Simon, A. Wuest, W. Luan, M. T. C. Fernandez, A. P. Kadina, J. A. Walker, K. Holden, F. J. Sanchez-Rivera, , L. E. Dow

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

B. D. Stein, J. R. Ferrarone, E. E. Gardner, J. W. Chang, D. Wu, Q. Chen, P. E. Hollstein, M. Yuan, R. J. Liang, J. S. Coukos, M. Sindelar, B. Ngo, S. S. Gross, R. J. Shaw, J. M. Asara, , L. C. Cantley

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

P. S. Dischinger, E. A. Tovar, C. J. Essenburg, Z. B. Madaj, E. E. Gardner, M. Callaghan, A. N. Turner, A. K. Challa, T. Kempston, B. Eagleson, R. A. Kesterson, R. T. Bronson, M. J. Bowman, C. R. Graveel, M. R. Steensma

This study shows NF1 deficiency in breast cancer correlates with estrogen receptor signaling and poor survival, using rat models and human genomic data.

bioRxiv · Feb 27, 2018Cancer Biology