S. Hoffmann

Validation of an MPS based intestinal cell culture model for the evaluation of drug-induced toxicity

This paper validates an MPS intestinal cell culture model for assessing drug-induced toxicity by comparing TEER measurements to 2D models and testing 23 compounds.

EGFR meets hATG8s - Biophysical and structural insights supporting a unique role of GABARAP during receptor trafficking

The paper identifies a GABARAP binding site on EGFR and shows its role in EGFR degradation through biophysical and structural analysis.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy gene transcripts

The paper identifies ANKS3/BICC1 as a post-transcriptional regulator of NPHP1 transcripts, linking it to ciliopathy phenotypes through transcript decay and ciliary dysfunction.

Early body weight gain in TALLYHO/JngJ mice predicts adult diabetic phenotype, mimicking childhood obesity

The paper identifies weaning body weight as a key predictor of adult diabetes in TALLYHO/JngJ mice, highlighting its relevance to childhood obesity research.

Highlighting the hidden: A tagging strategy for monitoring the association of GABARAP with microtubules in living cells

This study introduces a split-tandem GABARAP construct to monitor its association with microtubules in living cells, revealing a robust interaction not observed with N-terminal fluorescent tags.

Non-aging despite high mutation rate - genomic insights into the evolution of Hydra

This study examines Hydra's genome to understand its non-aging phenotype, finding no reduced mutation rate and identifying genes under selection related to regeneration and metabolism.

A chemotactic sensor controls Salmonella-host cell interaction

The paper shows that the chemotactic sensor CheM controls Salmonella's ability to invade host cells by regulating the surface retention of the adhesin SiiE.

Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics

The paper uses magnetic forces to manipulate a genomic locus in live human cells, revealing chromatin's viscoelastic properties and challenging the gel-like model.

The analysis of epigenomic evolution

The paper applies phylogenetic methods to epigenetic data, showing DNA methylation conservation and its correlation with transcription factor binding density in great apes.

Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disorders

The paper shows that gain-of-function mutations in FAM111A and FAM111B enhance protease activity, leading to DNA replication and transcription suppression and cell death, contributing to genetic disorders.

Structural and functional characterisation of SiiA, an auxiliary protein from the SPI4-encoded type 1 secretion system from Salmonella enterica

This study characterizes SiiA, a T1SS subunit in Salmonella, showing its PG-binding and proton translocation functions and linking them to Salmonella invasion.

Real Time de novo Deposition of Centromeric Histone-associated Proteins Using the Auxin Inducible Degradation System

The paper develops a method to study protein dynamics using auxin-inducible degradation, demonstrating real-time CENP-C deposition at centromeres.