D. K. Singh

The gut commensal Blautia maintains colonic mucus function under low fiber consumption through short-chain fatty acid-mediated activation of Ffar2

This study shows that the gut bacterium Blautia helps maintain colonic mucus function under low fiber diets by producing short-chain fatty acids that activate Ffar2.

A translation proofreader of archaeal origin imparts multialdehyde stress tolerance to land plants

This study shows that the archaeal DTD2 enzyme protects plants from aldehyde toxicity by removing harmful adducts on tRNA, and its overexpression enhances aldehyde resistance in Arabidopsis.

Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

Ethno-botanical Study of Medicinal Plants from Vidisha, Madhya Pradesh: Methanolic Extracts of Four Species and their Antimicrobial, Anti-inflammatory and Toxicity Properties

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells

This study shows macroH2A2 promotes dormancy in disseminated cancer cells, preventing metastasis without requiring known dormancy factors.

Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ-SMAD4 signaling.

The paper shows that AZA+atRA treatment induces dormancy in DCCs by restoring TGFβ-SMAD4 signaling, suppressing lung metastasis.

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

Protein kinase J regulates Rv0642c expression and sensitivity to rifampicin of mycobacteria

This study investigates the role of PknJ in regulating mmaA4 expression and rifampicin sensitivity in mycobacteria during extracellular and intracellular growth.

NG2+/Nestin+ mesenchymal stem cells dictate DTC dormancy in the bone marrow through TGFβ2

This study shows NG2+/Nestin+ mesenchymal stem cells in the bone marrow use TGFβ2 to induce dormancy in breast cancer disseminated tumor cells.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

This study identifies transcriptional signatures of IFN signaling and neutrophil degranulation in SARS-CoV-2 infected rhesus macaques and humans, highlighting age-related differences and shared pathways with tuberculosis.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase

The paper identifies PANS1 and PANS2 as the plant securin homologs, showing they antagonize separase to regulate chromosome separation in Arabidopsis.