Author

M. J. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

P. N. Paradkar· 3 shared I. Antoshechkin· 2 shared M. Dunn· 2 shared M. Li· 2 shared O. Akbari· 2 shared S. Jackson· 2 shared A. A. Hoffmann· 1 shared A. Buchman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBioengineering

P. N. Paradkar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineered Antiviral Sensor Targets Infected Mosquitoes

E. Dalla Benetta, A. J. Lopez-Denman, H.-H. Li, R. A. Masri, D. J. Brogan, M. Bui, T. Yang, M. Li, M. Dunn, M. J. Klein, S. Jackson, K. Catalan, K. R. Blasdell, P. Tng, I. Antoshechkin, , O. Akbari

The paper develops REAPER, a Cas13-based antiviral sensor that kills infected mosquitoes upon activation by arbovirus infection.

bioRxiv · Jan 27, 2023Bioengineering

Developing Wolbachia-based disease interventions for an extreme environment

P. A. Ross, S. Elfekih, S. Collier, M. J. Klein, S. S. Lee, M. Dunn, S. Jackson, Y. Zhang, J. K. Axford, X. Gu, M. S. Nasar, P. N. Paradkar, E. A. Tawfik, F. M. Jiggins, A. M. Almalik, , A. A. Hoffmann

This study evaluates Wolbachia strains in Saudi Arabian mosquitoes for dengue suppression in extreme environments, finding reduced heat tolerance and local adaptation effects.

bioRxiv · Jul 26, 2022Evolutionary Biology

Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody

A. Buchman, S. Gamez, M. Li, I. Antoshechkin, S.-H. Lee, S.-W. Wang, C.-H. Chen, M. J. Klein, J.-B. Duchemin, J. E. Crowe, P. N. Paradkar, O. Akbari

This paper develops genetically engineered Aedes aegypti mosquitoes expressing an engineered antibody that broadly neutralizes all four DENV serotypes, significantly reducing viral transmission.

bioRxiv · May 24, 2019Bioengineering