E. Schneider

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

This paper shows that SARS-CoV-2 Spike protein activates TMEM16F in platelets, enhancing pro-coagulant activity and thrombosis, which is inhibited by Niclosamide and Clofazimine.

TGF-β1 drives Th9 but not Treg cells upon allergen exposure

This study shows TGF-β1 promotes Th9 cells but not Tregs in allergic inflammation, suggesting TGF-β inhibition could be a therapeutic strategy for allergies and asthma.

Design, construction, and deployment of an affordable and long-lasting moored deep-water fish aggregation device

The paper describes the design and deployment of a durable, affordable deep-water FAD and discusses its potential as a scientific tool for pelagic species research and conservation.

Combined in silico docking and in vitro antiviral testing for drug repurposing identified lurasidone and elbasvir as SARS-CoV-2 and HCoV-OC43 inhibitors

The paper identifies lurasidone and elbasidone as inhibitors of SARS-CoV-2 and HCoV-OC43 through in silico docking and in vitro testing.

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

The paper identifies IL6 trans-signaling as a mechanism supporting DCC survival and outgrowth during clinical latency, with microenvironmental dependencies and PIK3CA mutations linked to metastatic progression.

CRISPR-Csy4-mediated editing of rotavirus double-stranded RNA genome

This study uses CRISPR-Csy4 to edit rotavirus dsRNA genome, enabling labeling of secondary transcription products and insights into viral replication.