M. Pascual

Novel role of Periploca laevigata extracts as anti-diabetic and anti-inflammatory function in pancreatic β cells exposed to hyperglycaemia

This study evaluates the anti-diabetic and anti-inflammatory effects of Periploca laevigata extracts on pancreatic β cells under hyperglycaemic conditions, showing upregulation of insulin and PDX-1 and downregulation of inflammatory markers.

Oleoylethanolamide effects on stress-induced alcohol consumption: a lipid at crossroads between stress, reward and neuroinflammation

This study shows that chronic OEA treatment after stress reduces stress-induced alcohol consumption in mice, but not relapse-like behavior.

Lipid network of plasma extracellular vesicles reveals sex-based differences in the lipidomic profile from patients with alcohol use disorder

This study uses lipidomics to analyze plasma extracellular vesicles from AUD patients and healthy individuals, revealing sex-based differences in lipid profiles and their potential links to disease mechanisms.

Variation in mutation, recombination, and transposition rates in Drosophila melanogaster and Drosophila simulans

The paper estimates mutation, recombination, and transposition rates in Drosophila melanogaster and D. simulans populations, finding variation between species, populations, and sexes.

Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections

This paper compares two methods for estimating malaria parasite multiplicity of infection under different transmission intensities, finding that varcoding is more robust in high-transmission settings while THE REAL McCOIL performs better in low-to-moderate transmission.

Frequency-dependent competition between strains imparts resilience to perturbations in a model of Plasmodium falciparum malaria transmission.

This paper shows that frequency-dependent selection increases resilience of malaria transmission systems to intervention compared to neutral processes.

Quantifying Climatic and Socio-Economic Influences on Urban Malaria in Surat, India: A Modelling Study

This study quantifies the joint influence of climate and socio-economic factors on urban malaria risk in Surat, India, using spatio-temporal modeling across multiple spatial resolutions.

The discovery, distribution and diversity of DNA viruses associated with Drosophila melanogaster in Europe

The paper identifies and characterizes DNA viruses in Drosophila melanogaster across Europe, revealing new viral lineages and prevalence patterns.

The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification

The paper models CRISPR-mediated host-virus interactions and shows empirical systems exhibit weighted-nested protection networks indicative of host suppression of virus diversification.

Genomic analysis of European Drosophila populations reveals major longitudinal structure, continent-wide selection, and unknown DNA viruses

The paper analyzes genomic variation in European Drosophila populations, revealing longitudinal structure, continent-wide selection, and new DNA viruses.

An antigenic diversification threshold for falciparum malaria transmission at high endemicity

The paper introduces a threshold for antigenic diversification in malaria, showing that reduced transmission can limit parasite genetic diversity and aid control efforts.

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

This study tests an intra-abdominal cooling device during open kidney transplantation in pigs, finding it reduces second warm ischemia time and improves renal function.

Seascape genetics at its finest: dispersal patchiness within a well-connected population

The paper detects fine-scale dispersal patterns in a well-connected marine population using genetic markers, otolith data, and spatial analysis, revealing complex dispersal dynamics influenced by environmental factors.

Enriched pathogen diversity under host-type heterogeneity and immune-mediated competition

The paper examines how host-type heterogeneity and immune-mediated competition affect pathogen diversity using a theoretical model inspired by rotavirus.

Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum

The paper shows immune selection generates persistent genetic modules in Plasmodium falciparum, which function as dynamic strains in host immune space.

Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

The paper develops neutral models to analyze genetic structure in Plasmodium falciparum and finds non-neutral strain organization in a Ghanaian population.