J. Walker

Between-day reliability of local and global muscle-tendon unit assessments in female athletes whilst controlling for menstrual cycle phase

This study assesses the test-retest reliability of local and global muscle-tendon unit function measurements in female athletes during the early follicular phase of the menstrual cycle.

Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing

The paper develops a method to deliver various RNA therapeutics, including mRNA and CRISPR-Cas9, to the lung using lipopolymer-lipid hybrid nanoparticles, showing improved efficacy and reduced toxicity.

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.

This study shows ERK signaling promotes resistance to TRK inhibitors in NTRK fusion-driven glioma mouse models and suggests MEK inhibition as a potential combination therapy.

Yellow Fever Emergence: Role of Heterologous Flavivirus Immunity in Preventing Urban Transmission

The paper shows that prior immunity to dengue and Zika viruses reduces yellow fever viremia, limiting mosquito infection and urban transmission risk.

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB

This study identifies ERRs as regulators of autophagy through TFEB activation in cardiomyocytes, suggesting ERR targeting as a therapeutic strategy for heart failure.

Alpaca Single B Cell Interrogation and Heavy-Chain-Only Antibody Discovery on an Optofluidic Platform

This paper develops a method to discover heavy-chain-only antibodies from alpaca B cells using an optofluidic platform and validates PSMA-specific VHH candidates.

Dating in the Dark: Elevated Substitution Rates in Cave Cockroaches (Blattodea: Nocticolidae) Have Negative Impacts on Molecular Date Estimates

The paper examines elevated substitution rates in cave cockroaches, showing their impact on molecular dating and phylogenetic analyses.

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

A high-throughput COPD bronchosphere model for disease-relevant phenotypic compound screening

This paper develops a high-throughput bronchosphere model for COPD and screens compounds to identify those that reverse CSE-induced phenotypic changes.

A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma

The paper develops a 3D microtissue model of asthmatic airway smooth muscle to identify contractile modulators and validate their effects through RNAseq analysis.

Introgression of the Triticum timopheevii genome into wheat detected by chromosome-specific KASP markers

The paper develops chromosome-specific KASP markers to detect introgression of Triticum timopheevii genome into wheat, identifying extensive recombination with wheat genomes.

Realtime morphological characterization and sorting of unlabeled viable cells using deep learning

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

Emergence of optrA-mediated linezolid resistance in multiple lineages and plasmids of Enterococcus faecalis revealed by long read sequencing

This study identifies multiple optrA-mediated linezolid resistance variants in Enterococcus faecalis using long-read sequencing, showing genetic diversity and plasmid variability.

Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

The paper identifies chemically modified crRNAs that enhance CRISPR-Cas13 knockdown efficiency and half-life in human cells.

Destructive fishing - A ubiquitously used but vague term? Usage and impacts across academic research, media and policy

This study examines the usage and impacts of the term 'destructive fishing' across academic, media, and policy sources from 1976-2020, revealing regional variations and calls for a unified definition.

Nurse cell-derived small RNAs define paternal epigenetic inheritance in Arabidopsis

The paper identifies nurse cell-derived small RNAs that establish paternal epigenetic inheritance in Arabidopsis by directing germline DNA methylation.

TMIGD1, a putative tumor suppressor, induces G2-M cell cycle checkpoint arrest in colon cancer cells

This study identifies TMIGD1 as a tumor suppressor that arrests the cell cycle in colon cancer cells and is downregulated in human CRC, correlating with poor survival.

Intragenic conflict in phylogenomic datasets

The paper examines intragenic conflict in phylogenomic datasets, finding high variability in conflict rates and identifying alignment errors as a major source.

Multi-proxy evidence for the impact of the Storegga Slide Tsunami on the early Holocene landscapes of the southern North Sea

The paper identifies Storegga Slide tsunami deposits in the southern North Sea using seismic surveys, sediment cores, and dating methods, showing localized and temporary impacts.

De novo origin of multicellularity in response to predation

This study shows that predation can drive the evolution of multicellularity in the green alga Chlamydomonas reinhardtii, with two populations developing multicellular structures that enhance survival against the predator Paramecium tetraurelia.

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

This study identifies Oncostatin M as a secreted niche factor that induces muscle stem cell quiescence and maintains their regenerative capacity.

Sexual lineage specific DNA methylation regulates Arabidopsis meiosis

This study identifies sexual lineage-specific DNA methylation in Arabidopsis that regulates meiosis by controlling gene expression through RNA-directed DNA methylation.

Improved Transcriptome Sampling Pinpoints 26 Paleopolyploidy Events In Caryophyllales, Including Two Paleo-Allopolyploidy Events

The paper identifies 26 paleopolyploidy events in Caryophyllales, including two paleo-allopolyploidy events, using dense transcriptome and genome sampling and novel analytical methods.