The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta signaling and Th17 responses in inflammatory arthritis.
M. Swart, A. Redpath, J. Ogbechi, R. Cardenas, L. Topping, E. B. Compeer, M. Goddard, A. Chanalaris, R. Williams, D. S. Brewer, N. Smart, C. Monaco, L. Troeberg
This study shows that SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis by modulating heparan sulfate remodeling.
bioRxiv · Mar 13, 2024Immunology