Author

K. Birsoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Khan· 2 shared E. R. Gamazon· 2 shared G. Unlu· 2 shared H. Alwaseem· 2 shared H.-W. Yeh· 2 shared R. K. Hite· 2 shared S. Heissel· 2 shared T. C. Kenny· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

A. Khan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

G. P. Donaldson, G. L. Reis, M. Saad, C. Wichmann, I. Mamede, G. Chen, C. E. Harrer, N. L. DelGaudio, D. Zhang, B. Aydin, T. B. R. Castro, S. Grivennikov, B. S. Reis, E. Liu, S. C. Eisenbarth, , D. Mucida

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

bioRxiv · Oct 6, 2023 · PreprintImmunology

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Y. Son, T. C. Kenny, A. Khan, K. Birsoy, R. K. Hite

This study identifies FLVCR1 as a transporter for choline and ethanolamine, revealing structural insights into its dual role in the Kennedy pathway.

bioRxiv · Sep 28, 2023Cell Biology

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

T. C. Kenny, A. Khan, Y. Son, L. Yue, S. Heissel, E. R. Gamazon, H. Alwaseem, R. K. Hite, K. Birsoy

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

bioRxiv · Oct 5, 2022Cell Biology

Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

G. Unlu, B. Prizer, R. Erdal, H.-W. Yeh, E. C. Bayraktar, K. Birsoy

The paper identifies SLCO2B1 as a heme transporter that enhances cellular iron availability under iron restriction, bypassing transferrin receptor-mediated uptake.

bioRxiv · Feb 6, 2022Cell Biology

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Y. Wang, F. S. Yen, X. G. Zhu, R. C. Timson, R. Weber, C. Xing, Y. Liu, B. Allwein, H. Luo, H.-W. Yeh, S. Heissel, G. Unlu, E. R. Gamazon, M. G. Kharas, R. Hite, K. Birsoy

This study identifies SLC25A39 as a mitochondrial glutathione importer and shows its role in cell proliferation and red blood cell development, with GSH availability regulating its abundance.

bioRxiv · Sep 15, 2021Biochemistry

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

bioRxiv · Feb 2, 2021Cancer Biology