Many are called but few are chosen - Multiple clonal origins greatly elevate the functional heterogeneity of tumors
B. Chen, X. Wu, Y. Ruan, Y. Zhang, H. Wen, P. Lan, C.-I. Wu
The paper shows that tumors can have multiple clonal origins, leading to high functional heterogeneity, with some tumors containing 13 independent clones and others having a dominant clone with minor patches.
bioRxiv · Sep 1, 2020 · PreprintCancer Biology