Y. Ruan

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

This study shows that warming and altered precipitation independently and together reduce alpine soil microbial growth by 40-90%, with some taxa showing increased growth under specific climate conditions.

The Generalized Haldane (GH) model tracking population size changes and resolving paradoxes of genetic drift

The paper integrates the Wright-Fisher and Haldane models to resolve paradoxes in genetic drift by defining it through variance in transmission success rather than population size.

LXA4 promotes the browning of white adipose through miR-133a-3p/SIRT1 pathway

This study shows LXA4 promotes white adipose browning and improves insulin resistance via the miR-133a-3p/SIRT1 pathway in mice.

The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

The paper uses the GH model to analyze genetic drift in mammalian rDNA genes, finding that fixation times are faster than expected, suggesting stronger drift or adaptive evolution.

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

The runaway evolution of SARS-CoV-2 leading to the highly evolved Delta strain

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

One viral sequence for each host? - The neglected within-host diversity as the main stage of SARS-CoV-2 evolution

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.

Multiple Mechanisms of HIV-1 resistance to PGT135 in Chinese Subtype B' Slow Progressor

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

Many are called but few are chosen - Multiple clonal origins greatly elevate the functional heterogeneity of tumors

The paper shows that tumors can have multiple clonal origins, leading to high functional heterogeneity, with some tumors containing 13 independent clones and others having a dominant clone with minor patches.

Sex, fitness decline and recombination - Muller's ratchet vs. Ohta's ratchet

The paper compares Muller's ratchet and Ohta's ratchet, finding that recombination may not significantly slow fitness decline in most parameter spaces.

Intracellular Delivery of Nanoparticles via Microelectrophoresis Technique: Feasibility demonstration

This paper demonstrates the feasibility of using microelectrophoresis to deliver nanoparticles into living cells, showing successful ejection of quantum dots into human kidney cells with minimal damage.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

Mutations beget more mutations - The baseline mutation rate and runaway accumulation

This paper proposes a runaway mutation model explaining how mutator mutations can lead to escalating mutation rates in both germline and somatic tissues, affecting evolutionary strategies across species.

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and - independent phagosomal signals that contribute to phagocytosis and inflammation

This study investigates MyD88-dependent and -independent phagosomal signaling in macrophages during Borrelia burgdorferi infection, showing their roles in phagocytosis and inflammation.

Coordinative Metabolism of Glutamine Carbon and Nitrogen in proliferating Cancer Cells Under Hypoxia

The paper identifies a hypoxia-specific metabolic pathway in cancer cells that redirects glutamine nitrogen to secretory dihydroorotate, avoiding ammonia toxicity and supporting tumor growth.