The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells
J. Zhang, S. Zhang, F. Wu…·D. Yang
The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.