J. Johnston

Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures

This paper develops a 3D culture platform using piezoelectric nanofibrous scaffolds with acoustic stimulation to significantly enhance small extracellular vesicle production.

Metatranscriptomic analysis reveals synergistic activities of comammox and anammox bacteria in full-scale attached growth nitrogen removal system.

The paper investigates how dissolved oxygen affects the synergistic nitrogen removal by comammox and anammox bacteria in wastewater treatment systems.

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

Deep reconstructing generative networks for visualizing dynamic biomolecules inside cells

The paper introduces cryoDRGN-ET, a deep generative model for reconstructing dynamic biomolecular structures from cryo-ET subtomograms, revealing ribosome states in yeast cells.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Comammox bacterial preference for urea influences its interactions with aerobic nitrifiers.

This study investigates how nitrogen source and loading conditions affect interactions between comammox bacteria and aerobic nitrifiers in continuous flow reactors, finding that urea promotes comammox abundance while ammonia inhibits it.

TRIB1 regulates tumour growth via controlling tumour-associated macrophage phenotypes and is associated with breast cancer survival and treatment response

This paper shows TRIB1 in macrophages affects breast cancer growth and treatment response by altering cytokine levels and immune cell composition.

Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

This study reports the crystal and cryo-EM structures of Ric-8A bound to Gαi1, revealing its mechanism of GTP exchange and chaperone activity through structural interactions.

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

This study shows that myeloid Trib1 promotes early atherosclerosis by enhancing foam cell formation through increased lipid uptake and OLR1 expression.

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium.

The paper shows neutrophil microvesicles deliver miR-155 to atheroprone endothelium, promoting vascular inflammation and atherosclerosis in mice.