I. Drulyte

Structural basis for inhibition of βFXIIa by garadacimab

This paper presents a high-resolution cryo-EM structure of garadacimab Fab bound to βFXIIa, revealing its unique binding mechanism and insights into FXII inhibition in HAE.

A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity

This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.

Sialoglycan binding triggers spike opening in a human coronavirus

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

Direct Cell Extraction of Membrane Proteins for Structure-Function Analysis

The paper develops a method to extract membrane proteins directly from cells into lipid nanoparticles and applies it to study the pannexin1 channel using SPR and cryo-EM.

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

Evolving cryo-EM structural approaches for GPCR drug discovery

This study validates stable GPCR:Gs complexes without Nb35 stabilizers and evaluates 200kV vs 300kV cryo-EM imaging for drug discovery.

A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain core

This paper identifies a human monoclonal antibody, 47D11, that targets a conserved hydrophobic pocket in the SARS-CoV-2 RBD, revealing its structural basis for neutralization and potential therapeutic use.

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

The paper presents the cryo-EM structure of HKU1 HE, revealing structural changes due to prolonged human circulation, including a truncated lectin domain and intact esterase domain.

Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidates

This paper develops potent anti-SARS-CoV-2 DARPin therapeutics with low picomolar neutralization efficacy and reports their protective efficacy in a hamster model.