Z. Tan

Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

This study shows that inhibiting Cx3cr1+iOCs enhances CGRP+TrkA+ sensory signaling and accelerates callus remodeling in osteoporotic fractures.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

Cationic Polymers Enable Internalization of Negatively Charged Chemical Probe into Bacteria

This study evaluates cationic polymers for delivering negatively charged ATP-based probes into bacteria, finding micellar polymers more effective than linear ones without causing significant toxicity.

Dominant and Genome-Wide Formation of DNA:RNA Hybrid G-Quadruplexes in Living Yeast Cells

The paper identifies hybrid G-quadruplexes (hG4s) in yeast cells, showing they dominate over DNA-only G4s and expand the number of G4-forming sites by over 15,000-fold.

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

Fast anther dehiscence state recognition system establishing by deep learning to screen heat tolerant cotton

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

Bifidobacteria-mediated immune system imprinting early in life

This study shows that lack of Bifidobacteria in early life is linked to immune dysregulation, and B. infantis EVC001 reduces intestinal Th2 and Th17 responses while promoting Th1 polarization.

SARS-CoV-2 Quasispecies provides insight into its genetic dynamics during infection

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

Binding of the SARS-CoV-2 Spike Protein to Glycans

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

Detect Genomic G-Quadruplexes in Living Animal Cells with a Tiny Artificial Protein Probe

The paper develops a small artificial protein probe to detect G-quadruplexes in living cells and identifies widespread G4 formation during transcription.

MYPT1 O-GlcNAcylation Dictates Timely Disjunction of Centrosomes

This study identifies MYPT1 O-GlcNAcylation as a regulator of centrosome disjunction during mitosis, showing that it modulates Plk1 activity and affects cell cycle progression.

Identification of Chikungunya virus nucleocapsid core assembly modulators

The paper identifies small molecules that modulate Chikungunya virus nucleocapsid core assembly and inhibit virus production in cell culture.

Extensive genetic diversity of bat-borne polyomaviruses reveals inter-family host-switching events

This study identifies extensive genetic diversity of bat-borne polyomaviruses and reports three inter-family host-switching events, challenging the notion of strict host restriction in mammalian PyVs.

Effect of soybean molasses-adsorbents on in vitro ruminal fermentation characteristics, milk production performance in lactating dairy cows

This study evaluates the effects of soybean molasses-adsorbents on in vitro ruminal fermentation and milk production in dairy cows, finding that wheat bran and soybean hulls improve fermentation and milk quality.

Chemically Accurate Relative Folding Stability of RNA Hairpins from Molecular Simulations

This study compares simulated and experimental free energies of RNA hairpins to assess force field accuracy and proposes methods to improve simulation convergence.

Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.