R. V. Farese

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

This study investigates how seipin's transmembrane segments contribute to triglyceride nucleation and lipid droplet budding using simulations and cell experiments.

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

This study shows that progranulin deficiency reduces bis(monoacylglycero)phosphate levels, leading to gangliosidosis and neurodegeneration.

The paper identifies two distinct pathways for ER-to-LD protein targeting and characterizes the molecular machinery involved.

This study identifies spartin as a receptor mediating selective autophagy of lipid droplets and links its dysfunction to Troyer syndrome.

This study identifies a second form of phosphatidylserine decarboxylase, PISD-LD, which localizes to lipid droplets and is regulated by nutritional state, revealing its role in neutral lipid storage.