J. Ho

Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma

Investigation of astrocytes' morphological changes in response to laser-induced shockwave

This study uses laser-induced shockwaves and quantitative phase microscopy to quantify astrocyte morphological changes, revealing significant alterations in shape and volume post-exposure.

Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

Role Of The C-C Motif Chemokine Ligand 5 (CCL5) And Its Receptor, C-C Motif Chemokine Receptor 5 (CCR5) In The Genesis Of Aldosterone-induced Hypertension, Vascular Dysfunction, And End-organ Damage

This study shows that CCL5/CCR5 contributes to aldosterone-induced hypertension, vascular injury, and renal damage by promoting inflammation and oxidative stress.

A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

This study identifies and characterizes SARS-CoV-2 Mpro mutations conferring resistance to nirmatrelvir using a VSV-based system and biochemical assays.

Antibody Neutralization of Emerging SARS-CoV-2: EG.5.1 and XBC.1.6

This study evaluates antibody neutralization resistance of SARS-CoV-2 variants EG.5.1 and XBC.1.6 using pseudovirus assays and sera/mAbs, finding distinct evasion profiles and suggesting immunological imprinting and non-evasion-driven prevalence.

SARS-CoV-2 Neutralizing Antibodies Following a Second BA.5 Bivalent Booster

This study evaluates the effect of a second BA.5 bivalent booster on SARS-CoV-2 neutralizing antibodies in elderly individuals, finding no significant increase in Omicron-specific titers after the second dose.

Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis

This study identifies extensive and persistent dermal fibrin deposition in systemic sclerosis, suggesting ongoing vascular leakage and impaired fibrin clearance contribute to fibrosis.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion

This study identifies distinct dopamine neuron functions in Drosophila that drive attraction and aversion during olfactory memory formation, showing separate roles for dopamine, glutamate, and octopamine.

Resistance of SARS-CoV-2 Omicron Subvariant BA.4.6 to Antibody Neutralization

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin

This study identifies EGFR-MAPK adaptor proteins that mediate epithelial responses to C. albicans via candidalysin, showing their role in ERK1/2 signaling and cytokine production.

A landscape of synergistic drug combinations in non-small-cell lung cancer

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

Deep Learning Predicts Patterns of Cardiotoxicity in a High-Content Screen Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes

This paper uses deep learning and high-content screening of iPSC-derived cardiomyocytes to predict cardiotoxicity patterns in 1280 compounds and identify cardiotoxic chemical frameworks.

Degradation of boscalid, pyraclostrobin, fenbuconazole, and glyphosate residues by an advanced oxidative process utilizing ultraviolet light and hydrogen peroxide

This study evaluates the degradation of four pesticide residues using an advanced oxidative process with H2O2 and UV-C light on apple surfaces and glass, finding similar degradation efficiency between AOP and individual treatments.

A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in regulatory T cells

This study identifies BRD9-containing non-canonical BAF complex as a regulator of Foxp3 in Tregs using a genome-wide CRISPR screen.

Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

This paper develops a toolkit for producing mutant and wild-type huntingtin proteins in eukaryotic systems to enable biochemical and structural studies of HD-related mutations.