S. Garrett

INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement

This study shows INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement through high-resolution imaging and genetic manipulation.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

Extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer

This study shows that intestinal vitamin D receptor deficiency promotes breast cancer by causing gut dysbiosis, increased inflammation, and microbial translocation.

Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiota

This study shows that intestinal epithelial Axin1 deficiency reduces susceptibility to colitis by altering gut microbiota composition and Paneth cell function.

Homologous recombination between tandem paralogues drives evolution of a subset of Type VII secretion system immunity genes in firmicute bacteria

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

This study shows that microbiome dysbiosis in ALS mice precedes motor neuron degeneration and affects intestinal neuromuscular function, with interventions improving symptoms.

Vitamin D Receptor Upregulates Tight Junction Protein Claudin-5 against Tumorigenesis

This study links VDR regulation of Claudin-5 to intestinal barrier function and tumorigenesis in colorectal cancer, showing VDR deficiency reduces Claudin-5 and increases tumor formation.

A phenotypically plastic magic trait promoting reproductive isolation in sticklebacks?

This study shows that an environmentally induced plastic trait in sticklebacks influences mate choice and contributes to reproductive isolation.