Author

E. Fikrig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Yang· 3 shared P. WANG· 3 shared T. Geng· 3 shared T. Lin· 3 shared A. T. Vella· 2 shared G. Cheng· 2 shared J. Hwang· 2 shared L. Yang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

D. Yang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metabolomic changes associated with acquired resistance to Ixodes scapularis

Y. Cui, J. Matias, X. Tang, B. Cibichakravarthy, K. DePonte, M.-J. Wu, E. Fikrig

This study identifies metabolomic changes in guinea pigs with acquired resistance to Ixodes scapularis ticks, showing that tyrosine pathway components like HPLA contribute to resistance.

bioRxiv · Jul 31, 2023 · PreprintBiochemistry

CD36 homologs determine microbial resistance to the Lyme disease spirochete

A. J. O'Neal, N. Singh, I. S. Forrest, A. Rolandelli, X. Wang, D. K. Shaw, B. D. Young, S. Narasimhan, S. Dutta, G. A. Snyder, L. Marnin, L. R. Butler, S. Samaddar, M. T. Mendes, F. E. C. Paz, , J. H. F. Pedra

The paper identifies CD36 homologs as conserved lipid receptors mediating anti-Borrelia immunity in both ticks and humans.

bioRxiv · Feb 9, 2022 · PreprintImmunology

The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

X. Tang, y. cao, G. Arora, J. Hwang, A. Sajid, C. Brown, S. Mehta, A. Marin-Lopez, Y.-M. Chuang, M.-J. Wu, H. Ma, U. Pal, S. Narasimhan, E. Fikrig

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

bioRxiv · Sep 13, 2021Microbiology

An Essential Role of UBXN3B in B Lymphopoiesis

T. Geng, D. Yang, T. Lin, A. G. Harrison, B. Wang, B. Torrance, K. Wang, Y. Wang, L. Yang, L. Haynes, G. Cheng, A. T. Vella, E. Fikrig, P. WANG

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

L. Yang, T. Geng, G. Yang, J. Ma, L. Wang, H. Ketkar, D. Yang, T. Lin, J. Hwang, S. Zhu, Y. Wang, J. Dai, F. You, G. Cheng, A. Vella, , P. WANG

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Communications Biology · Oct 8, 2020Peer-reviewedMicrobiology

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses

T. Lin, T. Geng, A. Harrison, D. Yang, A. T. Vella, E. Fikrig, P. Wang

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

bioRxiv · May 13, 2020 · PreprintImmunology