Multiple layers of innate immune response antagonism of SARS-CoV-2
F. Zhou, S. Periasamy, N. Jackson…·A. Bukreyev
This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.