Author

S. Schafer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. A. Widjaja· 3 shared B. NG· 3 shared E. Adami· 3 shared S. A. Cook· 3 shared S. Viswanathan· 3 shared J. Dong· 2 shared J. Tan· 2 shared M. Wang· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCell Biology

A. A. Widjaja

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Author profile →

4 papers

Recent·Most cited

Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

J. Dong, S. Viswanathan, E. Adami, S. Schafer, F. F. Kuthubudeen, A. A. Widjaja, S. A. Cook

The paper challenges the role of IL6 in liver regeneration, showing HyperIL6 protects against liver damage and promotes regeneration independently of STAT3, highlighting IL11 as a new therapeutic target.

bioRxiv · Apr 5, 2021 · PreprintCell Biology

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

A. A. Widjaja, J. R. Dong, E. Adami, S. Viswanathan, B. NG, B. K. Singh, W.-W. Lim, J. Zhou, L. S. Pakkiri, S. G. Shekeran, J. Tan, S. Y. Lim, M. Wang, R. Holgate, A. Hearn, , S. A. Cook

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

bioRxiv · Nov 4, 2019Physiology

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

B. Ng, J. Dong, S. Viswanathan, A. A. Widjaja, B. S. Paleja, E. Adami, N. S. J. Ko, M. Wang, S. Lim, J. Tan, S. P. Chothani, S. Albani, S. Schafer, S. A. Cook

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

bioRxiv · Oct 11, 2019Cell Biology

Interleukin 11 expression causes murine inflammatory bowel disease

W.-W. Lim, B. Ng, A. Widjaja, C. Xie, L. Su, N. Ko, S.-Y. Lim, X.-Y. Kwek, S. Lim, S. Cook, S. Schafer

This study shows that IL11 secretion from stromal cells drives inflammatory bowel disease in mice, suggesting IL11 as a therapeutic target for inflammatory bowel disease.

bioRxiv · Sep 5, 2019Pathology