A. Roux

Actin dynamics sustains spatial gradients of membrane tension in adherent cells

The paper demonstrates that adherent cells maintain spatial gradients of membrane tension through actin dynamics and membrane-cortex attachments, with tension lowest at adhesion edges and highest at protrusions.

Evolutionarily conserved principles of ESCRT-III-mediated membrane remodelling revealed by a two-subunit Asgard archaeal system

The paper identifies evolutionarily conserved principles of ESCRT-III-mediated membrane remodeling using an Asgard archaeal two-subunit system, showing homology to eukaryotic ESCRT-IIIB and IIIA.

Mechanism for Vipp1 spiral formation, ring biogenesis and membrane repair

The paper investigates how Vipp1 polymerizes into planar sheets and spirals on membranes, revealing geometric transitions that may inform ESCRT-III filament behavior.

CryoEM architecture of a native stretch-sensitive membrane microdomain

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.

Friction patterns guide actin network contraction

This study shows that friction forces between actin networks and their substrate guide contraction direction and speed, demonstrating the importance of resistive forces in cell shape control.

Modelling Membrane Reshaping by Staged Polymerization of ESCRT-III Filaments

The paper models how ESCRT-III filaments reshape membranes through staged polymerization and depolymerization, identifying mechanical conditions for membrane deformation and scission.

Technical insights into fluorescence lifetime microscopy of mechanosensitive Flipper probes

The paper optimizes fluorescence lifetime imaging (FLIM) for mechanosensitive Flipper probes to measure membrane tension and long-range forces in cells, tissues, and organs.

Membrane remodeling properties of the Parkinson's disease protein LRRK2

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction

This study shows retromer oligomerization drives SNX-BAR coat assembly and membrane constriction, with implications for cellular processes and disease.

Mechanochemical rules for shape-shifting filaments that remodel membranes

The paper develops a kinetic model to study how composite filaments remodel membranes by sequentially changing composition, showing this process lowers the energetic barrier for membrane deformation.

Vps60 initiates formation of alternative membrane-bound ESCRT-III filaments

The paper identifies Vps60 as a novel initiator of alternative membrane-bound ESCRT-III filaments that coexist with Snf7 filaments without interaction.

Pressure and curvature control of contact inhibition in epithelia growing under spherical confinement

This study shows that epithelial proliferation is regulated by tissue-level pressure via the β-catenin pathway and local curvature changes via the YAP/TAZ pathway under spherical confinement.

Quantitative coupling of cell volume and membrane tension during osmotic shocks

This study quantifies how cell volume and membrane tension change during osmotic shocks and shows they are coupled but not entirely independent.

Transient active osmotic swelling of epithelium upon curvature induction

This study shows that epithelial cells transiently swell osmotically in response to curvature changes using self-rolling substrates.

Mitochondrial membrane tension governs fission

The paper investigates mitochondrial fission dynamics, finding that membrane tension influences the likelihood of constrictions dividing.

Integer topological defects organize stresses driving tissue morphogenesis

The paper shows integer topological defects in myoblasts organize stresses that drive tissue differentiation and morphogenesis.

Cingulin unfolds ZO-1 and organizes myosin-2B and gamma-actin to mechanoregulate apical and tight junction membranes

This study shows cingulin regulates apical and tight junction membrane mechanics by organizing myosin-2B and gamma-actin and modulating ZO-1 conformation in MDCK cells.

Tracking crystallophore nucleating properties: setting-up a database for statistical analysis.

The paper introduces a database to analyze the nucleating properties of Crystallophore proteins and compares Tb-Xo4 with Lu-Xo4 for improved phasing.

Buckling of epithelium growing under spherical confinement

This study demonstrates that epithelial monolayers growing under spherical confinement can fold through buckling, showing forces and elastic properties drive the shape change.

Conserved function of ether lipids and sphingolipids in the early secretory pathway

The paper identifies hypersensitive mutants in lipid biosynthesis and trafficking genes in sphingolipid-depleted cells and shows coordinate regulation of ether and sphingolipids.

Vps4 triggers sequential subunit exchange in ESCRT-III polymers that drives membrane constriction and fission

The paper shows Vps4 drives sequential ESCRT-III subunit recruitment on membranes, leading to membrane constriction and fission.

Anisotropic ESCRT-III architecture governs helical membrane tube formation

The paper describes how ESCRT-III filaments assemble into helical membrane tubes through anisotropic architecture and mathematical modeling.

ENDOSOMAL MEMBRANE TENSION REGULATES ESCRT-III-DEPENDENT INTRA-LUMENAL VESICLE FORMATION

The paper shows that reduced endosomal membrane tension facilitates ESCRT-III polymerization and increases intra-lumenal vesicle formation.

TORC2 Affects Endocytosis through Plasma Membrane Tension

This study shows TORC2 regulates endocytosis by modulating plasma membrane tension, affecting adaptor protein interactions and vesicle fission protein recruitment.

Curvature Dependent constraints drive remodeling of epithelia

This study shows that epithelial cell detachment from a cylindrical shell depends on curvature and cell contractility, with J3B1A cells detaching more readily than MDCK cells.