Author

T. B. Kepler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

K. Wiehe· 3 shared B. F. Haynes· 2 shared K. O. Saunders· 2 shared M. Bonsignori· 2 shared P. D. Kwong· 2 shared T. Bradley· 2 shared A. Bartesaghi· 1 shared A. F. Nazzari· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

K. Wiehe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

N. Gao, Y. Gai, L. Meng, C. Wang, W. Wang, X. Li, T. Gu, M. K. Louder, N. A. Doria-Rose, K. Wiehe, A. F. Nazzari, A. S. Olia, J. Gorman, R. Rawi, W. Wu, , F. Gao

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

bioRxiv · Aug 7, 2021 · PreprintImmunology

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

W. B. Williams, R. Meyerhoff, R. J. Edwards, H. Li, N. Nicely, R. Henderson, Y. Zhou, K. Janowska, K. Mansouri, K. Manne, V. Stalls, A. L. Hsu, M. J. Borgnia, G. Stewart-Jones, M. S. Lee, , B. F. Haynes

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

bioRxiv · Jun 30, 2020 · PreprintImmunology

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

K. Wiehe, T. Bradley, R. R. Meyerhoff, C. Hart, W. Williams, D. Easterhoff, W. J. Faison, T. B. Kepler, K. O. Saunders, S. M. Alam, M. Bonsignori, B. F. Haynes

The paper identifies improbable mutations critical for HIV broadly neutralizing antibody development and proposes a mutation-guided vaccine strategy.

bioRxiv · Feb 9, 2018Immunology